Childhood Lymphoma

Childhood Lymphoma : what are Lymphomas?

Lymphomas are cancers of the lymphatic system, a key part of body’s immune system affecting both Children( Childhood lymphoma) and Adults. The lymphatic system includes a series of olive-sized nodes that produce lymph, a fluid that carries disease-fighting white blood cells (known as lymphocytes) throughout the body, and the tubes that carry this fluid.

Lymphomas are cancers of the lymphatic system, a key part of body’s immune system. The lymphatic system includes a series of olive-sized nodes that produce lymph, a fluid that carries disease-fighting white blood cells (known as lymphocytes) throughout the body, and the tubes that carry this fluid.

There are two types of lymphocytes affected by lymphoma: T cells and B cells, although B cell lymphomas are much more common.

There are several types of lymphoma, classified by how the cells appear under a microscope. In Hodgkin lymphoma, the disease is defined by the presence of Reed Sternberg cells, which are large cells that can have more than one nucleus. These cells grow and divide more quickly and live longer than normal cells. They also produce substances that encourage more healthy cells to gather in the lymph nodes. These healthy cells themselves produce substances that encourage the growth of Reed Sternberg cells. There are several subtypes of Hodgkin Lymphoma, but the vast majority are classical Hodgkin lymphoma.

Non-Hodgkin lymphoma (NHL), or simply lymphoma, does not have Reed Sternberg cells. There are several subtypes of NHL, including:

  • Burkitt’s Lymphoma (BL) affects B cell lymphocytes. It is one of the fastest-growing cancers.
  • Lymphoblastic Lymphoma (LBL) mostly affects T cell lymphocytes and is similar to acute lymphoblastic leukemia (ALL). It makes up about one-third of all childhood NHL, and is more common in boys.
  • Large Cell Lymphoma (LCL) includes two subtypes: diffuse large B-cell lymphoma (DLBCL) mostly affects pre-adolescent and teens; and anaplastic large cell lymphoma (ALCL) is more common in adolescents.

Childhood lymphoma risk factors

A risk factor is anything that increases the chances of a person developing a disease.

There are many different types of lymphoma, so not every risk factor applies to every type. In addition, most pediatric lymphoma patients don’t have any of the risk factors listed here (other than race and gender).

Nonetheless, the disease’s risk factors include:

Gender: Hodgkin lymphoma is more predominant in males than females.
Race: Whites are more likely to contract the disease than other groups.
Infections including Epstein-Barr virus, which causes mononucleosis, and HIV
Immune System diseases, including lupus and rheumatoid arthritis
Immune deficiency syndromes, including:
Ataxia-telangiectasia
Bloom syndrome
Common variable immunodeficiency
Severe combined immunodeficiency syndrome (SCID)
Wiskott-Aldrich syndrome
Taking immunosuppressants due to organ transplant

Having a parent or sibling with the diseaseSome cases of lymphoma can be passed down from one generation to the next. Genetic counseling may be right for you. At ACH, we know your child’s health and wellbeing are your number one concern. Our experts customize your child’s lymphoma treatment utilizing the most advanced treatments and techniques with the least impact on your child’s growing body.

Treatment at ACH:

A team of specially trained physicians follows your child throughout lymphoma treatment, all the way to survivorship. They communicate closely with each other, and with you, to ensure comprehensive, personalized care. They are supported by full complement of health care professionals dedicated to your child’s treatment, including nurses, physician assistants, therapists and others.