About Childhood Brain Tumor
Childhood Brain Tumor and spine tumors are the second most common cancers in children after leukemia.
Understanding The Brain :
The brain controls many important facets of everyday life, including emotions, thought, speech, vision, hearing and movement. The brain sends messages throughout the body via the spinal cord and cranial nerves in the head. The network of the brain and spinal cord is called the central nervous system (CNS).
Tumors can develop in the spinal cord and cranial nerves.
The hard, bony skull protects the brain, and the bones (vertebrae) of the spine protect the spinal cord. A liquid called cerebrospinal fluid (CSF) surrounds both the brain and the spinal cord.
The brain has four main parts:
Brain stem: Located at the base of the brain, the brain stem has nerve fibers that carry messages between the cerebrum and the rest of the body. A small but important area, the brain stem plays a part in breathing and heartbeat.
Cerebellum: At the back of the brain, this section helps control and coordinate movement, such as walking and swallowing.
Cerebrum: The outer and largest part of the brain. It has two halves called hemispheres and is responsible for emotions, reasoning, language, movement and the senses of seeing, hearing, smelling and touch; and the perception of pain.
Because the brain and spinal cord are made up of many kinds of tissues and cells, many types of tumors – both benign and malignant– can develop in these areas. These tumors may require different treatment and have different outlooks.
Even when brain tumors are benign, they can cause serious problems. Although non-cancerous brain tumors usually grow slower than cancerous brain tumors, they may damage and press against normal brain tissue or the spine as they grow.
Childhood brain Tumor and spinal cord tumors differ from adult tumors. The location where they develop, the type of cell in which they develop, and their treatment and outlook often are different. Brain tumors are classified by the types of cells they contain. This determines how they grow and what kind of treatment they require.
Childhood Brain Tumor most often found are :
Medulloblastoma: This is the most common type of malignant brain tumor in children. Learn more about medulloblastoma.
Astrocytoma: These form in the cerebrum in cells called astrocytes. They usually grow slowly, but higher-grade tumors spread more quickly. Since they mix with normal brain tissue, they can be difficult to remove surgically. They may spread along pathways of CSF but seldom spread outside the brain or spinal cord. Glioblastoma is the highest grade astrocytoma and the fastest growing.
Diffuse intrinsic pontine glioma: This dangerous tumor often has a poor prognosis. It grows in a vital area of the brain called the pons, which is in the brain stem.
Ependymomas develop in the brain lining, usually in the posterior fossa or along the spinal cord in glial cells. About five percent of childhood brain tumors are ependymomas. They begin in cells that line the ventricles or central canal of the spine. Ependymomas do not usually spread outside the brain or spinal cord, but they may block CSF, causing hydrocephalus.
Primitive neuroectodermal tumors (PNET): These aggressive tumors can develop anywhere in the brain, but they are usually in the frontal, temporal or parietal lobes.
Pineoblastomas: A type of PNET that develops in pineal gland and can be difficult to treat.
Craniopharyngiomas: These slow-growing tumors start above the pituitary gland but below the brain. They may press on the pituitary gland and hypothalamus, causing hormone problems. Since they start near the optic nerves, they can cause vision problems and be difficult to remove without damaging vision.
Mixed glial and neuronal tumors: Certain tumors that develop in children and young adults (and rarely in older adults) have both glial and neuronal cell components. They tend to have a fairly good prognosis.
- Pleomorphic xanthoastrocytoma (PXA) and dysembryoplastic neuroepithelial tumors (DNETs) look as if they could grow quickly when viewed under the microscope, but these tumors tend to be fairly benign, and most are cured by surgery alone.
- Ganglioglioma is a type of tumor that has both mature neurons and glial cells. Most can be cured by surgery alone or surgery combined with radiation therapy.
Choroid plexus tumors: These rare tumors start in the choroid plexus within the ventricles of the brain. Most are benign and can be removed by surgery.
Other tumors that start in or near the brain
Meningiomas: These tumors begin in the meninges, the tissue around the outer part of the brain and spine. They may press on the brain or spinal cord. Meningiomas are almost always benign and are usually cured by surgery. If they are near vital structures in the brain, they may need additional treatment.
Chordomas start in the bone at the base of the skull or at the lower end of the spine. They can injure the nervous system by pressing on it. They usually do not spread to other areas.
Germ cell tumors: Developing from germ cells, which normally form eggs in women and sperm in men, these are rare tumors. They form in the fetus when germ cells move to abnormal locations, including the brain. Germ cell tumors of the nervous system are usually found in children, most commonly in the pineal gland or above the pituitary gland. Learn more about childhood germ cell tumors.
Brain metastases: Cancers that metastasize (spread) to the brain from other areas of the body are called metastases. These are treated differently than primary brain cancers.
Childhood brain tumors risk factors
Anything that increases your child’s chance of getting a brain tumor is a risk factor. While no definite risk factors have been found for childhood brain tumors, some things may put your child at increased risk, including:
- Radiation exposure, particularly if your child was treated with radiation to the brain for leukemia. This late effect usually is seen between 10 to 15 years after treatment.
- Rare inherited genetic conditions, including:
- Tuberous sclerosis
- Neurofibromatosis types 1 and 2
- Von Hippel-Lindau disease
- Li-Fraumeni syndrome
- Other diseases that run in certain families, including:
- Turcot syndrome
- Rubinstein-Taybi syndrome
- Gorlin syndrome (basal cell nevus syndrome)
Some cases of brain cancer can be passed down from one generation to the next. Genetic counseling may be right for you.
ACH offers comprehensive, personalized care for benign (non-cancerous) and malignant (cancerous)for Childhood Brain Tumor. Our expert, highly specialized physicians and a dedicated support staff follow your child every step of the way, collaborating and communicating closely.
We provide the most advanced diagnostic and treatment approaches, many of which are available at only a few hospitals in the nation. Our surgeons are top in their fields, and their expertise helps target the tumor while saving as much of the surrounding tissue as possible.
Formation of Tumor:
In a fetus, germ cells are cells that should become sperm in the testicles or eggs in the ovaries. Sometimes these cells don’t travel to the right part of the body and end up forming a tumor. These tumors can be either benign or malignant, meaning they can spread to other parts of the body. Malignant tumors are cancer.
One way to classify germ cell tumors is based on where they form. Most malignant germ cell tumors are gonadal, meaning they’re in either the ovaries or testes. They can also form in the brain’s pineal gland, near the pituitary gland.
Other places they form include the:
Back
Coccyx, or tailbone
Mediastinum, the area between the lungs
Neck
Sacrum, a large bone in the lower spine that forms part of the pelvis
Germ cell tumors are also defined by how they look under a microscope and/or the hormones they produce.
Teratomas are usually benign, but some are malignant. Teratomas of the tail bone are the most common germ cell tumor found in children, and are about four times more common in girls than in boys.
Germinomas make the beta-human chorionic gonadotropin hormone. Those that form in the ovaries are called dysgerminomas, while ones in the testes are seminomas. They can also appear outside the ovaries or testes. In these cases, they’re simply called germinomas.
Non-germinomas include:
Yolk sac tumors, also known as endodermal sinus tumors. They can form in the ovaries, testes or other parts of the body. They are the most common type of testicular cancer in infants and children.
Embryonal carcinoma. These are malignant and most commonly found in the testicles, but can spread to other parts of the body.
Gonadoblastomas, which are rare, almost always benign tumors associated with abnormal development of the reproductive organs.
Polyembryomas. They are a very rare, aggressive type of germ cell tumor that is usually found in the ovaries.
Childhood germ cell tumors risk factors
There are several factors that seem to increase the risk of a child developing a germ cell tumor.
Certain genetic conditions are tied to increased risk for specific types of germ cell tumors:
Klinefelter syndrome may increase a person’s chances of developing a tumor in the mediastinum, the area between the lungs.
Swyer syndrome may increase a person’s chance of developing a germ cell tumor in the ovaries or testicles.
Turner syndrome may increase the risk of ovarian germ cell tumors.
In addition, having an undescended testicle increases the odds of a male developing a testicular germ cell tumor.
A family history of germ cell tumors also increases the chance that someone will develop a germ cell tumor.